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Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event

10 Sept 2018

Abstract excerpt

The standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contrast, many works have shown that the progression of MM is also characterized by the selection of clones with extended...

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PMID: 30250824
DOI: 10.3389/fonc.2018.00355

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