Article
Molecular dynamics simulations provide molecular insights into the role of HLA-B51 in Behçet's disease pathogenesis.
Chemical biology & drug design - 1 Jul 2020
Gur Mert, Golcuk Mert, Gul Ahmet, Erman Burak
Abstract excerpt
Behçet's disease is an inflammatory disorder of unknown etiology. Genetic tendency has an important role in its pathogenesis, and HLA-B51, a class I MHC antigen, has been recognized as the strongest susceptibility factor for Behçet's disease. Despite the confirmation of the association of HLA-B51 with Behçet's disease in different populations, its pathogenic mechanisms remain elusive. HLA-B51 differs in only two...
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