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Article

Structural Modulation and Binding of HLA-DQ8 by Cysteine-to-Serine Mutated Insulin Peptide: Insights from Molecular Dynamics Simulations.

International journal of molecular sciences - 27 May 2026

Mittal Rahul, Karki Ukesh, Lemos Joana R N, Chapagain Prem, Hirani Khemraj

Abstract excerpt

Type 1 diabetes (T1D) is driven by autoreactive CD4+ T-cell responses to pancreatic beta cell antigens presented by disease-associated human leucocyte antigen (HLA) class II molecules. However, the molecular mechanisms by which subtle antigenic modifications promote pathogenic immunity remain incompletely defined. Recent immunopeptidomic studies have identified a cysteine-to-serine substitution at position 19 of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42278376
DOI: 10.3390/ijms27114846
PMCID: PMC13256993

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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