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A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

15 Oct 2021

Abstract excerpt

A hexanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Toxic dipeptide repeats (DPRs) are synthesized from GGGGCC via repeat-associated non-AUG (RAN) translation. Here, we develop C. elegans models that express, either ubiquitously or exclusively in neurons, 75 GGGGCC repeats flanked...

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PMID: 34654821
DOI: 10.1038/s41467-021-26303-x

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A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translationPMID 34654821Read ↗

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