Article

A <i>C. elegans</i> model of <i>C9orf72</i> -associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation

2020-06-15

Abstract excerpt

<h4>ABSTRACT</h4> A hexanucleotide repeat expansion GGGGCC in the noncoding region of C9orf72 is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Potentially toxic dipeptide repeats (DPRs) are synthesized from the GGGGCC sequence via repeat associated non-AUG (RAN) translation. We developed C. elegans models that express, either ubiquitously or exclusivel...

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Literature Corpus work: 1b730fca-a0ca-5ee9-9a6c-a29f8466950a
DOI: 10.1101/2020.06.13.150029

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