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Article

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

21 Apr 2023

Abstract excerpt

BACKGROUND: Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactylation is a novel lactate-derived posttranslational modification that plays key roles in multiple cellular processes. Since hypoxia in ischemic retinopathy is a precipitating factor for retinal...

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PMID: 37085894
DOI: 10.1186/s13059-023-02931-y

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