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In celebration of a century with insulin - Update of insulin gene mutations in diabetes.

Molecular metabolism - 1 Oct 2021

Støy Julie, De Franco Elisa, Ye Honggang, Park Soo-Young, Bell Graeme I, Hattersley Andrew T

Abstract excerpt

BACKGROUND: While insulin has been central to the pathophysiology and treatment of patients with diabetes for the last 100 years, it has only been since 2007 that genetic variation in the INS gene has been recognised as a major cause of monogenic diabetes. Both dominant and recessive mutations in the INS gene are now recognised as important causes of neonatal diabetes and offer important insights into both the...

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Identifiers

PMID: 34174481
DOI: 10.1016/j.molmet.2021.101280
PMCID: PMC8513141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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