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Article

Glial overexpression of Tspo extends lifespan and protects against frataxin deficiency in Drosophila

14 May 2024

Abstract excerpt

The translocator protein TSPO is an evolutionary conserved mitochondrial protein overexpressed in various contexts of neurodegeneration. Friedreich Ataxia (FA) is a neurodegenerative disease due to GAA expansions in the FXN gene leading to decreased expression of frataxin, a mitochondrial protein involved in the biosynthesis of iron-sulfur clusters. We previously reported that Tspo was overexpressed in a...

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PMID: 38750879
DOI: 10.1016/j.biochi.2024.05.003

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