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Article

The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2018

Korkegian Aaron, O'Malley Theresa, Xia Yi, Zhou Yasheen, Carter David S, Sunde Bjorn, Flint Lindsay, Thompson Dean, Ioerger Thomas R, Sacchettini Jim, Alley M R K, Parish Tanya

Abstract excerpt

We identified a series of novel 7-phenyl benzoxaborole compounds with activity against Mycobacterium tuberculosis. Compounds had a range of activity with inhibitory concentrations (IC90) as low as 5.1 μM and no cytotoxicity against eukaryotic cells (IC50 > 50 μM). Compounds were active against intracellular mycobacteria cultured in THP-1 macrophages. We isolated and characterized resistant mutants with mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29523334
DOI: 10.1016/j.tube.2017.11.003
PMCID: PMC5854369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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