Article

BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

2024-05-01

Abstract excerpt

Elastic cartilage constitutes a major component of the external ear, which functions to guide sound to the middle and inner ears. Defects in auricle development cause congenital microtia, which affects hearing and appearance in patients. Mutations in several genes have been implicated in microtia development, yet, the pathogenesis of this disorder remains incompletely understood. Here, we show that Prrx1 genetical...

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Literature Corpus work: 73f7f086-4a91-5dc8-bceb-152a1b4b8818
DOI: 10.7554/elife.91883.3

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