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Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

26 Apr 2010

Abstract excerpt

A population of stromal cells that retains osteogenic capacity in adult bone (adult bone stromal cells or aBSCs) exists and is under intense investigation. Mice heterozygous for a null allele of prkar1a (Prkar1a(+/-)), the primary receptor for cyclic adenosine monophosphate (cAMP) and regulator of protein kinase A (PKA) activity, developed bone lesions that were derived from cAMP-responsive osteogenic cells and...

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PMID: 20421483
DOI: 10.1073/pnas.1003680107

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