Article

In-cell processing enables rapid and in-depth proteome analysis of low-input <i>Caenorhabditis elegans</i>

2024-09-19

Abstract excerpt

Caenorhabditis elegans is a widely used genetic model organism, however, the worm cuticle complicates extraction of intracellular proteins, a prerequisite for typical bottom-up proteomics. Conventional physical disruption procedures are not only time-consuming, but can also cause significant sample loss, making it difficult to perform proteomics with low-input samples. Here, for the first time, we present an on-fi...

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Literature Corpus work: 73efac57-e98c-5e58-a481-8bfd95ee042c
DOI: 10.1101/2024.09.18.613705

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