Article

From Mutation to Metabolism: Root Cause Analysis of Cancer’s Initiating Drivers

2025-09-10

Abstract excerpt

<h4>Background: </h4> /Objectives: Despite decades of focus on the Somatic Mutation Theory (SMT), survival outcomes for cancer remain modest, with most therapies offering only marginal benefits. Mounting evidence suggests that mitochondrial dysfunction, rather than random mutations, represents the central initiating event in carcinogenesis. <h4>Methods:</h4> We applied a systems-based Root Cause Analysis (RCA) fra...

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Literature Corpus work: a0c71889-3fc4-534c-a503-43e9a7d48a88
DOI: 10.20944/preprints202509.0903.v1

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