Article

PopTradeOff: a database for exploring population-specific trade-offs between adaptive evolution, disease susceptibility, and drug responsiveness

2023-02-10

Abstract excerpt

The influence of adaptive evolution on disease susceptibility has drawn attention, but the extent of the influence, whether favored mutations also influence drug responses, and whether the associations between the three are population specific remain little known. Using a deep learning network to integrate seven statistical tests for detecting selection signals, we predicted favored mutations in the genomes of 17...

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Literature Corpus work: 73dd6b82-8fee-5428-b37d-b6dac691fc7b
DOI: 10.1101/2023.02.09.527958

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