Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease.

doi:10.1053/j.gastro.2024.09.021

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Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease.

Gastroenterology - 1 Feb 2025

Horn Veronika, Cancino Camila A, Steinheuer Lisa M, Obermayer Benedikt, Fritz Konstantin, Nguyen Anke L, Juhran Kim Susan, Plattner Christina, Bösel Diana, Oldenburg Lotte, Burns Marie, Schulz Axel Ronald, Saliutina Mariia, Mantzivi Eleni, Lissner Donata, Conrad Thomas, Mashreghi Mir-Farzin, Zundler Sebastian, Sonnenberg Elena, Schumann Michael, Haag Lea-Maxie, Beule Dieter, Flatz Lukas, Trajanoski Zlatko, D'Haens Geert, Weidinger Carl, Mei Henrik E, Siegmund Britta, Thurley Kevin, Hegazy Ahmed N

Abstract excerpt

BACKGROUND & AIMS: Despite the success of biological therapies in treating inflammatory bowel disease, managing patients remains challenging due to the absence of reliable predictors of therapy response. METHODS: In this study, we prospectively sampled 2 cohorts of patients with inflammatory bowel disease receiving the anti-integrin α4β7 antibody vedolizumab. Samples were subjected to mass cytometry; single-cell...

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PMID: 39343250
DOI: 10.1053/j.gastro.2024.09.021

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