Article

Activation of the SARS-CoV-2 Receptor <i>Ace2</i> by Cytokines Through Pan JAK-STAT Enhancers

2020-05-22

Abstract excerpt

ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu et al., 2020), raising the possibility that ACE2 expression is under the control of cytokines through the JAK-ST...

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Literature Corpus work: 735d5c7c-a283-5d4e-98ca-30cfb430b407
DOI: 10.2139/ssrn.3601827

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