Article

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

2020-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Coronavirus disease (COVID-19), caused by SARS-CoV-2, has affected over 65 million individuals and killed over 1.5 million persons (December 8, 2020; www.who.int ) 1 . While fatality rates are higher among the elderly and those with underlying comorbidities 2 , host factors that promote susceptibility to SARS-CoV-2 infection and severe disease are poorly understood. Although individuals with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22d22bf8-2ccd-5860-a67f-68e40b1510d4
DOI: 10.1101/2020.12.09.416586

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse CellsDOI 10.1101/2020.12.09.416586Read

ACE2 and COVID-19 Susceptibility and SeveritySemantic proximity Read

SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigeneticsSemantic proximity Read

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.Semantic proximity Read

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesisSemantic proximity Read

Impacts of host factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression.Semantic proximity Read

Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal CellsSemantic proximity Read

SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targetsSemantic proximity Read

From bedside to bench: regulation of host factors in SARS-CoV-2 infection.Semantic proximity Read

Molecular mechanisms of Thalidomide effectiveness on COVID-19 patients explained: ACE2 is a new ΔNp63α target geneSemantic proximity Read

IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 AxisSemantic proximity Read

Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification.Semantic proximity Read

Immune interaction map of human SARS-CoV-2 target proteins: implications for therapeutic avenuesSemantic proximity Read