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Maternal malnutrition in mice impairs nephrogenesis by disrupting DNA methylation of regulatory regions

17 Oct 2024

Abstract excerpt

Our study establishes a direct link between maternal caloric restriction, DNA methylation patterns in nephron progenitor cells, and kidney development. We reveal consistent alterations in methylation patterns, coupled with corresponding shifts in the expression of genes related to kidney development and cell proliferation. Methionine supplementation emerges as a promising intervention, effectively restoring...

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PMID: 39417827
DOI: 10.1152/ajprenal.00169.2024

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