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Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD

7 Jul 2020

Abstract excerpt

There is greater than tenfold variation in nephron number of the human kidney at birth. Although low nephron number is a recognized risk factor for CKD, its determinants are poorly understood. Evolutionary medicine represents a new discipline that seeks evolutionary explanations for disease, broadening perspectives on research and public health initiatives. Evolution of the kidney, an organ rich in mitochondria,...

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PMID: 35372951
DOI: 10.34067/kid.0002012020

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