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Article

Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach.

Psychological medicine - 1 Oct 2021

Liu Congcong, Xu Lei, Li Jialin, Zhou Feng, Yang Xi, Zheng Xiaoxiao, Fu Meina, Li Keshuang, Sindermann Cornelia, Montag Christian, Ma Yina, Scheele Dirk, Ebstein Richard P, Yao Shuxia, Kendrick Keith M, Becker Benjamin

Abstract excerpt

BACKGROUND: Early life stress has been associated with emotional dysregulations and altered architecture of limbic-prefrontal brain systems engaged in emotional processing. Serotonin regulates both, developmental and experience-dependent neuroplasticity in these circuits. Central serotonergic biosynthesis rates are regulated by Tryptophan hydroxylase 2 (TPH2) and transgenic animal models suggest that TPH2-gene...

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PMID: 32981537
DOI: 10.1017/S0033291720002809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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