Article

An ancient gene duplication is implicated in virulence in the human pathogen, <i>Histoplasma</i>

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Histoplasma spp. is a dimorphic fungal primary pathogen that infects people worldwide and frequently affects immunosuppressed patients. Previous studies have identified the AMY1 gene product, the α-amylase Amy1p, as essential for α-glucan production and virulence in Histoplasma capsulatum . We identified two new genes ( AMY2 and AMY3 ) in the Histoplasma genome that encode putative α-amylas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72ea36c9-9ed0-5711-80a3-c0fcb4f3d17c
DOI: 10.64898/2026.02.25.708051

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An ancient gene duplication is implicated in virulence in the human pathogen, <i>Histoplasma</i>DOI 10.64898/2026.02.25.708051Read

An α‐(1,4)‐amylase is essential for α‐(1,3)‐glucan production and virulence in <i>Histoplasma capsulatum</i>Semantic proximity Read

Genotypic diversity, virulence, and molecular genetic tools in Histoplasma.Semantic proximity Read

Chromosome-level genome assembly of a human fungal pathogen reveals synteny among geographically distinct speciesSemantic proximity Read

Recyclable CRISPR/Cas9 mediated gene disruption and deletions in <i>Histoplasma</i>Semantic proximity Read

Phenotypic characterization of cryptic species in the fungal pathogen <i>Histoplasma</i>Semantic proximity Read

A remarkable expansion of secreted cysteine knot proteins reveals novel virulence factors in the human fungal pathogen <i>Histoplasma</i>Semantic proximity Read

Recyclable CRISPR/Cas9-mediated gene disruption and deletions in HistoplasmaSemantic proximity Read

Genome Dynamics and Chromosome Structural Variations in <i>Histoplasma ohiense</i> , a fungal pathogen of humansSemantic proximity Read

Expression of Paracoccidioides brasiliensis AMY1 in a Histoplasma capsulatum amy1 mutant, relates an α-(1,4)-amylase to cell wall α-(1,3)-glucan synthesis.Semantic proximity Read

Identification of essential genes and fluconazole resistance genes in <i>Candida glabrata</i> by profiling of <i>Hermes</i> transposon insertionsSemantic proximity Read

Dandruff-associated <i>Malassezia</i> genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogensSemantic proximity Read

Overlooked <i>Candida glabrata</i> petites are echinocandin tolerant, induce host inflammatory responses, and display poor <i>in vivo</i> fitnessSemantic proximity Read