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Recyclable CRISPR/Cas9-mediated gene disruption and deletions in Histoplasma

11 Oct 2023

Abstract excerpt

ABSTRACT Targeted gene disruption is challenging in the dimorphic fungal pathogen Histoplasma due to the low frequency of homologous recombination. Transformed DNA is either integrated ectopically into the genome or maintained extrachromosomally by de novo addition of telomeric sequences. Based on a system developed in Blastomyces , we adapted a CRISPR/Cas9 system to facilitate targeted gene disruption in...

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PMID: 37819140
DOI: 10.1128/msphere.00370-23

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