Article
Expression of Paracoccidioides brasiliensis AMY1 in a Histoplasma capsulatum amy1 mutant, relates an α-(1,4)-amylase to cell wall α-(1,3)-glucan synthesis.
PloS one - 1 Jan 2012
Camacho Emma, Sepulveda Victoria E, Goldman William E, San-Blas Gioconda, Niño-Vega Gustavo A
Abstract excerpt
In the cell walls of the pathogenic yeast phases of Paracoccidioides brasiliensis, Blastomyces dermatitidis and Histoplasma capsulatum, the outer α-(1,3)-glucan layer behaves as a virulence factor. In H. capsulatum, an α-(1,4)-amylase gene (AMY1) is essential for the synthesis of this polysaccharide, hence related to virulence. An orthologous gene to H. capsulatum AMY1 was identified in P. brasiliensis and also...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.