Article

Deciphering the Impact of miR-92a-3p on Controlling BCL11A Gene Expression and Its Implication in Easing Thalassemia Symptoms

2024-11-01

Abstract excerpt

Abstract Background: Thalassemia, a prevalent genetic disorder, is characterized by a point mutation affecting the globin gene expression. One manifestation of this disorder, β -thalassemia, arises from compromised β -globin chain production. Objectives: The objective of this research was to explore the presence of miR-92a expression in the bloodstream of individuals affected by severe thalassemia. Moreover, the s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72dc88fc-a249-5dcf-aeaf-8a30e4d7dafc
DOI: 10.4103/mjbl.mjbl_1337_23

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering the Impact of miR-92a-3p on Controlling BCL11A Gene Expression and Its Implication in Easing Thalassemia SymptomsDOI 10.4103/mjbl.mjbl_1337_23Read

Upregulation of miR‑6747‑3p affects red blood cell lineage development and induces fetal hemoglobin expression by targeting BCL11A in β‑thalassemiaSemantic proximity Read

Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11ASemantic proximity Read

MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.Semantic proximity Read

miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11ASemantic proximity Read

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene ExpressionSemantic proximity Read

MicroRNAs in β-thalassemia.Semantic proximity Read

The clinical value of hsa-miR-190b-5p in peripheral blood of pediatric β-thalassemia and its regulation on BCL11A expressionSemantic proximity Read

The role of miR-129-5p in regulating γ-globin expression and erythropoiesis in β-thalassemiaSemantic proximity Read

Regulation of miR-17-3p on K562 cell proliferation and erythroid differentiation as well as γ-globin expression in patients with β-thalassemiarSemantic proximity Read

[Quantitative analysis of human globin gene expression in beta-thalassemia using real-time RT-PCR].Semantic proximity Read

Relative and Absolute Quantification of Aberrant and Normal Splice Variants in HBBIVSI-110 (G > A) β-Thalassemia.Semantic proximity Read

Peripheral blood circular RNA circ-0008102 may serve as a novel clinical biomarker in beta-thalassemia patientsSemantic proximity Read