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Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A

30 May 2025

Abstract excerpt

BACKGROUND: Large number of microRNAs (miRNAs) have been found to be dysregulated in β-thalassemia, but their roles in β-thalassemia are poorly reported. This study aims to investigate the clinical significance of miR-17-3p in β-thalassemia, and to elucidate its regulatory effect on erythropoiesis and γ-globin expression. METHODS: We collected peripheral blood samples from 17 patients with β-thalassemia...

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PMID: 40448206
DOI: 10.1186/s13023-025-03806-0

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