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The role of miR-129-5p in regulating γ-globin expression and erythropoiesis in β-thalassemia

8 Dec 2024

Abstract excerpt

The regulation of γ-globin expression is crucial due to its beneficial effects on diseases like β-thalassemia and sickle cell disease. B-cell lymphoma/leukemia 11A (BCL11A) is a significant suppressor of γ-globin, and microRNAs (miRNAs) targeting BCL11A have been shown to alleviate this suppression. In our previous high-throughput sequencing, we identified an 11.32-fold increase in miR-129-5p expression in...

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PMID: 39657657
DOI: 10.1093/hmg/ddae180

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