Article
MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.
PloS one - 1 Jan 2013
Lulli Valentina, Romania Paolo, Morsilli Ornella, Cianciulli Paolo, Gabbianelli Marco, Testa Ugo, Giuliani Alessandro, Marziali Giovanna
Abstract excerpt
MicroRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNAs target. The functional relevance of microRNAs has been proven in normal and malignant hematopoiesis. While analyzing miRNAs expression profile in unilineage serum-free liquid suspension unilineage cultures of peripheral blood CD34(+) hematopoietic progenitor cells (HPCs) through the erythroid,...
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