Article

Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes Towards a Purkinje Fiber Fate

2024-09-23

Abstract excerpt

Cardiac Purkinje fibers form the most distal part of the ventricular conduction system. They coordinate contraction and play a key role in ventricular arrhythmias. While many cardiac cell types can be generated from human pluripotent stem cells, methods to generate Purkinje fiber cells remain limited, hampering our understanding of Purkinje fiber biology and conduction system defects. To identify signaling pathway...

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Literature Corpus work: 72d248e2-08c8-57fc-b2b9-8dc081ac8d82
DOI: 10.1101/2024.09.22.614353

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