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Article

A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2023

Langa Paulina, Shafaattalab Sanam, Goldspink Paul H, Wolska Beata M, Fernandes Aurelia A, Tibbits Glen F, Solaro R John

Abstract excerpt

In this perspective, we discussed emerging data indicating a role for Notch signalling in inherited disorders of the heart failure with focus on hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) linked to variants of genes encoding mutant proteins of the sarcomere. We recently reported an upregulation of elements in the Notch signalling cascade in cardiomyocytes derived from human inducible...

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Identifiers

PMID: 37122209
DOI: 10.1098/rstb.2022.0176
PMCID: PMC10150215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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