Article

Intra-subtype heterogeneity shapes treatment response in <i>KMT2A</i> -rearranged ALL across all age groups

2025-06-09

Abstract excerpt

<h4>Background</h4> KMT2A -rearranged B-cell acute lymphoblastic leukemia ( KMT2A r B-ALL) exhibits significant heterogeneity in age of onset, developmental origins, and clinical outcomes. The interplay of individual factors influencing early treatment response within this high-risk molecular subtype remains poorly elucidated. We aimed to comprehensively assess how leukemic developmental state, fusion partner, a...

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Literature Corpus work: 72c8a105-1dec-5e8f-b3f9-7a3420e65052
DOI: 10.1101/2025.06.05.657589

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