Article

The influence of copy number variation at the 22q11.2 locus on brain function

2021-01-01

Abstract excerpt

Increased striatal dopamine synthesis capacity (DSC) and Glx (the combination of glutamate and glutamine) levels in anterior cingulate cortex (ACC), striatum and thalamus have been implicated in the pathophysiology of schizophrenia. However, there is only limited evidence in genetic high-risk groups. 22q11.2 deletion is the strongest genetic risk factor for schizophrenia, whereas the reciprocal duplication protect...

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Literature Corpus work: 72ad46e1-62c4-59f6-8f01-9b08d274fe5f
DOI: 10.25560/89257

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