Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2019

Rogdaki Maria, Hathway Pamela, Gudbrandsen Maria, McCutcheon Robert A, Jauhar Sameer, Daly Eileen, Howes Oliver

Abstract excerpt

Glutamatergic dysregulation is one of the leading theories regarding the pathoaetiolopy of schizophrenia. Meta-analysis of magnetic resonance spectroscopy studies in schizophrenia shows increased levels of glutamate and glutamine (Glx) in the medial frontal cortex and basal ganglia in clinical high-risk groups for psychosis and increased glutamine levels in the thalamus, but it is unclear if this is also the case...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corpus Striatum
Share to DiGeorge Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Glutamine

Share to Gyrus Cinguli

Share to Magnetic Resonance Spectroscopy

Share to Psychotic Disorders

Share to Thalamus

Source

Identifiers

PMID: 31648854
DOI: 10.1016/j.euroneuro.2019.09.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion.PMID 31648854Read ↗

Nature of Glutamate Alterations in Schizophrenia: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.Semantic proximity Read ↗

Excitatory inhibitory imbalance underlies hippocampal atrophy in individuals with 22q11.2 Deletion Syndrome with psychotic symptomsSemantic proximity Read ↗

Glutamate and psychosis risk.Semantic proximity Read ↗

Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in SchizophreniaSemantic proximity Read ↗

A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganizationSemantic proximity Read ↗

Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.Semantic proximity Read ↗

Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy.Semantic proximity Read ↗

3-T proton MRS investigation of glutamate and glutamine in adolescents at high genetic risk for schizophrenia.Semantic proximity Read ↗

Proton Magnetic Resonance Spectroscopy in 22q11 Deletion SyndromeSemantic proximity Read ↗

The influence of copy number variation at the 22q11.2 locus on brain functionSemantic proximity Read ↗

7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings.Semantic proximity Read ↗

Glutamate, NAA and Energy Metabolism in Clinical High Risk and First Episode PsychosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.