Article

CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndrome

2026-01-09

Abstract excerpt

<h4>Introduction</h4> The podocyte slit diaphragm (SD) is a complex filtration unit localized to the blood and urine interface and governs the glomerular selectivity. However, the greater details of the SD composition and the mechanism of assembly of the SD protein as a macromolecular complex remain elusive. CD2-associated protein (CD2AP) serves as a central scaffold within the SD, and mutations in CD2AP are stro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 729ec7b4-6b43-5445-8304-2be3a2c835cb
DOI: 10.64898/2026.01.08.698362

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD2AP’s Structure and Oligomerization are compromised by the K301M mutation: implications for Nephrotic syndromeDOI 10.64898/2026.01.08.698362Read

Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragmSemantic proximity Read

SNP in Slit-Diaphragm Proteins is Associated with Altered Physicochemical Properties: Consequences for Impaired Glomerular Filtration Barrier FunctionSemantic proximity Read

In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants.Semantic proximity Read

CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS).Semantic proximity Read

Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains.Semantic proximity Read

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.Semantic proximity Read

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.Semantic proximity Read

PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicitySemantic proximity Read

Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration BarrierSemantic proximity Read

Structural and molecular basis of the assembly of the TRPP2/PKD1 complexSemantic proximity Read

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot processSemantic proximity Read

Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease.Semantic proximity Read