Article

SNP in Slit-Diaphragm Proteins is Associated with Altered Physicochemical Properties: Consequences for Impaired Glomerular Filtration Barrier Function

2026-05-29

Abstract excerpt

The glomerular filtration barrier (GFB), localized at the interface of blood and urine, is crucial for renal filtration. Slit diaphragm (SD), a specialized intercellular junction between adjacent podocytes, is a significant component of GFB. Several transmembrane proteins (nephrin, NEPH1, and TRPC6) and adapter proteins (podocin and CD2AP) are tethered together and form a highly complex SD. Non-synonymous single-n...

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Literature Corpus work: 6554bc0f-5f0a-5b71-a6e0-83afdad3dd89
DOI: 10.20944/preprints202605.2033.v1

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