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Article

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.

PloS one - 1 Jan 2013

Gödel Markus, Ostendorf Benjamin N, Baumer Jessica, Weber Katrin, Huber Tobias B

Abstract excerpt

Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the space between adjacent podocyte foot processes in the kidney glomerulus. Dislocation and misexpression of slit diaphragm components have been described in the...

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Source

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Identifiers

PMID: 23437316
DOI: 10.1371/journal.pone.0057078
PMCID: PMC3577791

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems.PMID 23437316Read ↗

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Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.Semantic proximity Read ↗

Selective endocytosis controls slit diaphragm maintenance and dynamicsSemantic proximity Read ↗

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Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations.Semantic proximity Read ↗

Structural conformations of intrinsically disordered proteins of podocyte slit-diaphragmSemantic proximity Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

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NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome.Semantic proximity Read ↗

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