Article
In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants.
IUBMB life - 1 Jul 2016
Mulukala Sandeep Kumar Narasimha, Nishad Rajkishor, Kolligundla Lakshmi Prasanna, Saleem Moin A, Prabhu Nagu Prakash, Pasupulati Anil Kumar
Abstract excerpt
Nephrotic syndrome (NS) is manifested by hyperproteinuria, hypoalbuminemia, and edema. NPHS2 that encodes podocin was found to have most mutations among the genes that are involved in the pathophysiology of NS. Podocin, an integral membrane protein belonging to stomatin family, is expressed exclusively in podocytes and is localized to slit-diaphragm (SD). Mutations in podocin are known to be associated with...
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