Article

Identification of the Down syndrome critical region 3 gene as a mammalian cell size regulator

2026-07-24

Abstract excerpt

Using a genetic screening approach based on an inducible gene-activating system and cell sorting, Down syndrome critical region 3 (DSCR3) was isolated as a gene whose overexpression increased cell size. Fibroblasts derived from individuals with Down syndrome (DS) exhibit elevated DSCR3 expression at both the mRNA and protein levels, correlating with increased cell volume compared to fibroblasts from healthy donors...

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Literature Corpus work: 729064f2-b35a-5a5f-9e9b-2c3304f2dc0f
DOI: 10.64898/2026.07.23.740440

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