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Article

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

21 Apr 2017

Abstract excerpt

Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21. Abnormalities in chromosome number have the potential to lead to disruption of the proteostasis network (PN) and accumulation of misfolded proteins. DS individuals suffer from several comorbidities, and we hypothesized that disruption of proteostasis could contribute to the observed pathology and decreased cell viability in DS. Our...

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PMID: 28430800
DOI: 10.1371/journal.pone.0176307

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