Article

Down syndrome fibroblasts exhibit diminished autophagic clearance and endosomal dysfunction after serum starvation

2018-10-05

Abstract excerpt

Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21 (Tri21). This unbalanced karyotype has the ability to produce proteotoxic stress and dysfunction of the proteostasis network (PN), which are mechanistically associated with several comorbidities found in the DS phenotype. Autophagy is the cellular process responsible for bulk protein degradation and its impairment could negatively impact p...

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Literature Corpus work: 82693ec0-2189-5eae-9c9d-9442d4183ebc
DOI: 10.1101/436782

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