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Article

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function.

Nature neuroscience - 1 Nov 2005

Chang Karen T, Min Kyung-Tai

Abstract excerpt

Mitochondrial dysfunction has emerged as a common theme that underlies numerous neurological disorders, including Down syndrome. Down syndrome cultures and tissues show mitochondrial damage such as impaired mitochondrial enzyme activities, defective mitochondrial DNA repairs and accumulation of toxic free radicals, but the cause of mitochondrial dysfunction remains elusive. Here we demonstrate that the Drosophila...

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Identifiers

PMID: 16222229
DOI: 10.1038/nn1564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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