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Article

Down Syndrome Critical Region 1 Gene, Rcan1 , Helps Maintain a More Fused Mitochondrial Network

23 Jan 2018

Abstract excerpt

Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca 2+ -activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down syndrome critical region. The hearts and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion (I/R); however, the underlying cause is not known. Objective: Mitochondria...

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PMID: 29362227
DOI: 10.1161/circresaha.117.311522

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