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Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells

13 Jan 2017

Abstract excerpt

Alterations in mitochondrial activity and morphology have been demonstrated in human cells and tissues from individuals with Down syndrome (DS), as well as in DS mouse models. An impaired activity of the transcriptional coactivator PGC-1α/PPARGC1A due to the overexpression of chromosome 21 genes, such as NRIP1/RIP140, has emerged as an underlying cause of mitochondrial dysfunction in DS. We tested the hypothesis...

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PMID: 28087733
DOI: 10.1093/hmg/ddx016

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