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Article

Sterical hindrance promotes selectivity of the autophagy cargo receptor NDP52 for the danger receptor galectin-8 in antibacterial autophagy.

Science signaling - 5 Feb 2013

Li Sai, Wandel Michal P, Li Fudong, Liu Zhonghua, He Chao, Wu Jihui, Shi Yunyu, Randow Felix

Abstract excerpt

Autophagy, the process of lysosome-dependent degradation of cytosolic components, is a mechanism by which cells selectively engulf invading pathogens to protect themselves against infection. Galectin-8, a cytosolic protein with specificity for β-galactoside-containing glycans, binds endosomal and lysosomal membranes that have been damaged, for example, by pathogens, and selectively recruits the autophagy cargo...

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Identifiers

PMID: 23386746
DOI: 10.1126/scisignal.2003730
PMCID: PMC3713453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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