Article

Predicting the functional impact of single nucleotide variants in <i>Drosophila melanogaster</i> with FlyCADD

2025-03-06

Abstract excerpt

Understanding how genetic variants drive phenotypic differences is a major challenge in molecular biology. Single nucleotide polymorphisms form the vast majority of genetic variation and play critical roles in complex, polygenic phenotypes, yet their functional impact is poorly understood from traditional gene-level analyses. In-depth knowledge about the impact of single nucleotide polymorphisms has broad applicat...

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Literature Corpus work: a3b42cff-09d2-5c60-8368-6203b9c3f123
DOI: 10.1101/2025.02.27.640642

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