Article

Harnessing Escherichia coli’s Dark Genome to Produce Anti-Alzheimer Peptides

2023-06-24

Abstract excerpt

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration. The critical molecular trigger is believed to be the accumulation of Aβ neurotoxic oligomers. Given the proteolytic processing of Amyloid Precursor Protein (APP) by β-secretase (beta-site APP cleaving enzyme 1, BACE1) as the key step in the building up of Aβ oligomers, BACE inhibitors come with therapeutic prospects of preventing or delayi...

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Literature Corpus work: 726c6638-416d-554f-833b-cfeada9d47d8
DOI: 10.1101/2023.06.23.546343

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