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Biofilm Biology to Brain Health: Harnessing Microbial Wisdom to Uncover Amyloid Dissociating Bifunctional Nano Chaperones for Alzheimer’s Therapeutics

18 Apr 2025

Abstract excerpt

Microbial infections have long been implicated in the gut-brain link to Alzheimer’s disease (AD). These infections may influence AD development either directly, through brain invasion, or indirectly via bacterial metabolites crossing the blood-brain-barrier (BBB) or interacting with the enteric nervous system (ENS). Such findings have inspired clinicians to repurpose antimicrobial drugs for AD, yielding promising...

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PMID: 40247766
DOI: 10.1021/acschemneuro.4c00868

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