Article

Autoantigen TRIM21 (Ro52) assembles pro-inflammatory immune complexes following lytic cell death

2024-09-10

Abstract excerpt

Sjögren’s disease (SjD) causes localised and systemic inflammation due to autoantibody production against intracellular proteins, such as TRIM21/Ro52. TRIM21 is an E3 ubiquitin ligase which binds antibody Fc domains on opsonised pathogens, which have escaped extracellular immunity and entered cytosols; TRIM21 ubiquitinates these, driving their proteasomal degradation. How and why TRIM21 becomes an autoantigen rema...

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Literature Corpus work: 724138d3-0246-52e0-8579-86da57122cc1
DOI: 10.1101/2024.09.06.611470

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