Article

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis

2023-10-23

Abstract excerpt

<h4>Background: </h4> Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined the role of CatD in the development of Aβ pathology and tauopathy in vivo. Methods CatD knockout (KO) mice were crossed to human amyloid precursor protein (hAPP) transg...

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Literature Corpus work: 71ef45c0-64bd-5da6-b437-808a2f541073
DOI: 10.21203/rs.3.rs-3464352/v1

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