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Article

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Neuron - 21 Sept 2006

Mueller-Steiner Sarah, Zhou Yungui, Arai Hideaki, Roberson Erik D, Sun Binggui, Chen Jennifer, Wang Xin, Yu Guiqiu, Esposito Luke, Mucke Lennart, Gan Li

Abstract excerpt

Alzheimer's disease (AD) may result from the accumulation of amyloid-beta (Abeta) peptides in the brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase Abeta production. Here, we demonstrate that CatB actually reduces levels of Abeta peptides, especially the aggregation-prone species Abeta1-42, through proteolytic cleavage. Genetic...

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Identifiers

PMID: 16982417
DOI: 10.1016/j.neuron.2006.07.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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