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Article

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.

Neuron - 23 Oct 2008

Sun Binggui, Zhou Yungui, Halabisky Brian, Lo Iris, Cho Seo-Hyun, Mueller-Steiner Sarah, Devidze Nino, Wang Xin, Grubb Anders, Gan Li

Abstract excerpt

Impaired degradation of amyloid beta (Abeta) peptides could lead to Abeta accumulation, an early trigger of Alzheimer's disease (AD). How Abeta-degrading enzymes are regulated remains largely unknown. Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recently discovered Abeta-degrading enzyme. A CST3 polymorphism is associated with an increased risk of...

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Identifiers

PMID: 18957217
DOI: 10.1016/j.neuron.2008.10.001
PMCID: PMC2755563

Genes

CST3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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